The EM ACE600 is a versatile high vacuum film deposition system, designed to produce very thin, fine-grained, and conductive metal and carbon coatings for the highest resolution analysis, as required for FE-SEM and TEM applications. This fully automated table-top coater includes an integrated oil-free pumping system, quartz crystal film thickness measurement and three axis motorized stage (rotation, optional tilt and height).

Producing homogenous and conductive metal or carbon coatings for SEM and TEM analysis was never more convenient than with the Leica EM ACE200 coating system. Configured as a sputter coater or carbon thread evaporation coater, perfectly reproducible results can be achieved in the fully automated system. If both methods are required for your analysis Leica Microsystems offers a combined instrument with interchangeable heads in one instrument. Various options as Quartz Crystal Measurement, Planetary Rotation, Glow Discharge, and Exchangeable Shielding complete this Low Vacuum Coater.

With the DVM6, you can get from the big picture to smallest details in an instant. You can seamlessly carry on working even if changing objective is required, as the sample always stays in focus and no pre-adjustments are needed. With the tilting function you can observe your sample from different angles from up to ±60° With the DVM6, you can get from the big picture to smallest details in an instant. You can seamlessly carry on working even if changing objective is required, as the sample always stays in focus and no pre-adjustments are needed. With the tilting function you can observe your sample from different angles from up to ±60°. - Manual or motorized versions - Zoom module with 16:1 zoom range - Magnification from 12x to 2,350x depending of the objective selected - 2350x magnification shows you details down to 0.4 micrometers on the same microscope - Integrated 10 Megapixel high resolution camera - Integrated ring ling and coaxial LED illumination - PlanApo-corrected Leica Optics with long working distance - Available version with tilting stand for one handed operation tilting from -60° to +60° - LAS X Software If you work in quality control/assurance, failure analysis, research and development, or in forensics, searching for the detail can take up a lot of your time in microscopy. The DVM6 digital microscope is a fast, reliable and easy to use solution that combines outstanding optics, intuitive operation, and smart software to save you time. Save time for 2D and 3D analysis Optimize your workflow with the DVM6 digital microscope LAS X software from Leica Microsystems. LAS X.next, a streamlined software user interface, helps you to save time when acquiring 2D and 3D scanned images*. This makes task-flows clearer, simpler and intuitive for operators due to its streamlined user interface and fast navigation. Carry out your component analysis faster. LAS X.next guides you through image acquisition, measurement**, and reporting, providing an efficient workflow and reliable reproducibility of results. It provides a straightforward operation for the DVM6 system for faster completion of your work steps. Benefit from Fast and straightforward navigation: Predefined task-flows help to reduce complexity, therefore saving time for users with different levels of experience Smart illumination: Assisted image brightness algorithms make it effortless to get the perfect image setting Easy acquisition of 2D and 3D images: Use interactive scan points to define a scan area or volume * Results depend on sample, used objective, zoom and microscope settings. ** Measurement results depend on used objective, zoom and microscope settings. Why you can reproduce results easily Zoom range is continuously encoded and calibrated All instrument components are sensor-controlled All settings saved with every image, e.g. illumination, position, magnification Create a report for 2D and 3D measurements with one click Accuracy matters – tested and guaranteed The repeatability of the stage and focus column for DVM6 A/S is: XY-Axis: +/- 3um Z-Axis: +/- 0.5um The linearity of the stage and focus column is: XY-Axis: 0.2% Z-Axis: 0.1% Ease of use: One step from macro to micro With the DVM6, you can get from the big picture to smallest details in an instant. You can seamlessly carry on working even if changing objective is required, as the sample always stays in focus and no pre-adjustments are needed. With the tilting function you can observe your sample from different angles from up to ±60°. Why the Leica DVM6 saves you time 16:1 zoom range makes changing between magnifications fast 2350x magnification shows you details down to 0.4 micrometers on the same microscope Horizontal field of view ranges from 35 mm to 0.18 mm at same focus level One-hand operation You will become an expert in virtually no time! Work seamlessly thanks to one-handed objective change Stay focused and operate the tilting function with one hand Hybrid manual-motorized operation of X, Y and Z - smart automation helps you to be faster Easy to operate, so little training time is needed Image quality: See more with crisper images Obtain excellent image quality! The Leica DVM6 has top notch optics that the Leica brand is famous for. Choose from different integrated LED illumination options and reveal more details. Capture your image in natural colors with a high-resolution camera. High quality objectives for your inspection and imaging tasks Easily change magnification from 12x to 2,350x with one hand to inspect your samples. Choose the PlanApo objective that best fits your needs, and see more with the 16:1 zoom range. Low Magnification Objective: Leica PlanApo FOV 43.75 This objective is ideally suited for large overviews as well as detailed measurement tasks. It provides you with magnifications up to 190x and long working distances up to 60 mm. Mid Magnification Objective: Leica PlanApo FOV 12.55 This flexible objective for your everyday routine work features a wide magnification range. You can quickly and easily gain more insight with 46x to 675x magnification and keep a comfortable 33 mm working distance. High Magnification Objective: Leica PlanApo FOV 3.60 This high power objective is ideally suited for magnification up to 2,350x at 425 nm resolution. Enjoy working with this objective to see more details thanks to the PlanApo corrected zoom optics from Leica Microsystems. Why you can discover more with the Leica DVM6 10-megapixel high-resolution camera Fast live image display with more than 30 frames per second More details with excellent PlanApo-corrected Leica optics Illuminate your sample uniformly even at large field of view Combine illumination and contrasting options in various ways to highlight your sample features best Discover your possibilities with optional accessories With a wide variety of illumination options and accessories you can: Explore hard-to-image regions of interest with the BLI Transmitted Illumination Adapter (Backlight Illumination) for precise analysis of thermal vias in PCBs or inspection of transparent materials, for example. Effectively reduce glare on reflective samples, such as polished metal surfaces with the Diffusor Adapter. Accurately identify particle contamination or material properties with the Polarizer Adapter. Easily access any sample, even if it is large or bulky with a larger microscope stand - the DVM6 interface module allows you to mount the zoom module onto an XL focus column from Leica Microsystems. Find your Leica DVM6 configuration The Leica DVM6 digital microscope is available in three different configurations to help you find the solution that best fits your application and budget needs. Choose between three options Do you need high resolution images and application versatility? The DVM6 C is the perfect microscope if you cannot compromise on image quality. Are you also looking for multi-focus images and 3D-analysis? With the DVM6 S you add the comfort of a motorized focus to the imaging capabilities. And you will love the autofocus. Would you also like to scan larger areas in high resolution? The DVM6 A is the recommended microscope if versatility is required. You can capture large images in XYZ with just a single click. Adaptable to larger samples Leica DVM6 M – Digital Microscope Zoom Module If your sample is too large or bulky for the standard Leica DVM6 configurations, the modular DVM6 M offers you more configuration flexibility for a wide range of applications. With a special interface adapter, the DVM6 M zoom module can be used with selected stands from the Leica M series. This allows you to examine larger and higher samples. Customize the DVM6 M to your needs. For large surface inspection of automotive parts DVM6 M with Low magnification objective PlanApo FOV 43.75 Motorized focus with profile column 620 mm M series Universal base plate, XL Feature list Leica DVM6 Manual or motorized versions All system components encoded – also for the manual version Motorized versions are hybrid and can be operated manually as well for fast coarse positioning Zoom module with 16:1 zoom range Integrated 10-megapixel high-resolution camera PlanApo-corrected Leica optics with long working distance Motorized and software-controlled Iris diaphragm Integrated ring light and coaxial LED illumination Snap-on adapters for ring light contrasting (polarizer, diffusor, low angle illumination) Backlight illumination for translucent samples Tilting stand for one-handed operation, tilting from -60° to +60° Focus drive with a travel range of 60 mm XY stage with a travel range of 70 mm x 50 mm Autofocus with two options: one shot on region of interest, or continuous autofocus LAS X software

The modular DMi8 inverted microscope is the heart of the DMi8 S platform solution. For routine to live cell research, the DMi8 S platform is a complete solution. Whether you need to precisely follow the development of a single cell in a dish, screen through multiple assays, obtain single molecule resolution, or tease out behaviors of complex processes, a DMi8 S system will enable you to see more, see faster, and find the hidden. Flexibility is built-in, allowing you to add established options like DIC for unstained samples and Intelligent Automation. For time-lapse experiments use precise focus control with Adaptive Focus Control and Closed Loop FocusThis novel design facilitates the integration of additional fluorescence light sources and laser systems for advanced applications like: FRAP photo-switching ablation optogenetics Every DMi8 comes standard with 19mm field of view (FOV) for all camera ports. Configure your system with a variety of contrast method, add sophisticated modalities like TIRF

The Leica DM IL LED features a comprehensive set of contrast methods to monitor your specimen the way you need. High-quality Phase contrast, excellent modulation contrast and brilliant fluorescence are just one fingertip away. Robust stability, plenty of space to work with tools, long working distances to accommodate large culture flasks and a stable illumination without heat make work at the microscope easy and convenient For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) including in-vitro-fertilization (IVF).

Designed to help you maximize efficiency, Leica DCM8 unites the advantages of High Definition confocal microscopy with interferometry into one versatile, dual-core system. Ultra-fast analysis is ensured thanks to one-click mode selection, sophisticated software and HD confocal scanning without moving parts. - Measuring Principle Dual Core Optical Imaging Profilometry (Confocal and Interferometry) non-contact, 3D - Contrast modes HD Confocal, HD Interferometry (PSI, ePSI, VSI), HD Brightfield Color, Brightfield, Darkfield, Real Time HD RGB Confocal - Sample height 40 mm standard; up to 150 mm with adjustable column; larger sample height possible on request - Vertical scan range Confocal 40 mm, PSI 20 mm, ePSI 100 mm, VSI 10 mm - Illumination LED light sources: red (630 nm), green (530 nm), blue (460 nm) and White - Image Acquisition CCD B&W Sensor: 1360 x 1024 pixels (full resolution); B&W 35 FPS True Color / Confocal: 3 FPS (full resolution), 10 FPS (half resolution), 15 FPS Live Confocal - Vibration Isolation Active or passive - Repeatability (50 x magnification) Confocal / VSI: error = 0.003 mm (3 nm); PSI: error = 0.16 nm (0.00016 mm) - Accuracy (20 x magnification) With open loop: < 3% relative error; with closed loop: < 20 nm error

Products – Page 8 – DMI Medical USA

Q: Leica EM ICE | High Pressure Freezer

High pressure freezing is key for the study of intricate changes in fine structure or cellular dynamics. Cryo-immobilize your aqueous samples under high pressure with a unique freezing principle and uncover secrets of the cellular process. Capture and resolve highly dynamic processes at the nanometer scale with millisecond precision. The EM ICE solution, combining superior high pressure freezing with the possibility of light and electrical stimulation, is the platform for your discoveries LN 2 Consumption Value LN 2 consumption during cool down 80lts 8 liters LN 2 consumption in operation including cool down 30lts 30 liters LN 2 consumption per freezing process 80ml 80 ml

Q: Leica EM GP2 | Automatic Plunge Freezer

The EM GP2 plunge freezes fluid or extremely thin samples spread on an electron microscopy grid into liquid ethane after removing excess fluid by automatic blotting. Prior to freezing the sample is maintained in a temperature and humidity controlled environmental chamber, adjustable between +4°C and +60°C and room humidity to 99 %. Safe and reproducible preparation for single particle analysis and cryo-tomography.

Q: Leica EM CDT | Cryo Tool Drying

During Cryo preparation, tools such as forceps and sample holders often ice over and cannot be immediately used for the next sample run. De-icing and drying of the tools at room temperature is time consuming and can cause damage to sensitive components and may prevent their operation. The special combination of heated air flow and heating plate completely dries tools, even on their difficult to access inner surfaces. The maximum temperature of + 50°C ensures that the cryo tools dry without heat damage and protect the user from the risk of burns

Q: Leica EM AFS2 and EM FSP

Freeze Substitution and Low Temperature Embedding System The Leica EM AFS2 performs freeze substitution and progressive lowering of temperature (PLT) techniques and allows low temperature embedding and polymerization of resins. The Leica EM FSP (freeze substitution processor), an automatic reagent handling system combined with the Leica EM AFS2, dispenses reagents for both freeze substitution and PLT applications. The LED illumination from within the chamber and the attached stereomicroscope for viewing and positioning of samples ensures ease of use Reduces set-up time Automatic dilution of reagents from 100% stock containers reduces user reagent handling and set-up time. Specimens remain dry Adjustable transfer function of gaseous LN2 allows the chamber and specimens to remain dry, which results in no contamination of the specimen One Step preparation Fast UV polymerization with LED UV lamp results in one-step preparation for the user; samples and reagents can be added and left until the end of the run –140 °C to +70 °C working range AFS smart-remote observation of the process and delivery of critical information via SMS Stereomicroscope viewing

Q: Leica EM ACE900 | Freeze Fracturing System

The Leica EM ACE900 is a high-end sample preparation system for freeze fracturing, freeze etching and high resolution cryo coating. This instrument is easy and intuitive to use. To achieve highest sample protection sample transfer, large cryo-shields, and the sample shutter are optimized. Users obtain best results because the instrument stays always in high vacuum. This is provided by a load lock system, a knife transfer, and gate valves for each e-beam source. The perfect combination of automation and optional manual operation makes the preparation process highly reproducible and flexible. Versatility, speed, and yield of your sample preparation is incomparable

Q: Leica DVM6 Video Microscopes

The DVM6 digital microscope is a fast, reliable, and easy to use solution that combines outstanding optics, intuitive operation, and smart software to save you time Zoom range is continuously encoded and calibrated All instrument components are sensor-controlled All settings saved with every image, e.g. illumination, position, magnification Create a report for 2D and 3D measurements with one click Accuracy matters – tested and guaranteed The repeatability of the stage and focus column for DVM6 A/S is: XY-Axis: +/- 3um Z-Axis: +/- 0.5um The linearity of the stage and focus column is: XY-Axis: 0.2% Z-Axis: 0.1%

Q: Leica DSM300 Video Microscopes

The Leica DMS300 is a complete digital microscope system that utilizes a HDMI-monitor instead of eyepieces. Leica’s high quality 8:1 zoom optics are combined with a 2.5MP camera to provide a full high-definition live image with up to 30fps. The Leica DMS300 produces high-quality, full-color still images as well as Full-HD movies as a standalone system. All primary functions of the DMS300 are controlled with a wireless remote control. Additionally, it can be connected to a computer offering full compatibility with Leica software LAS EZ

Leica EM ICE | High Pressure Freezer

High pressure freezing is key for the study of intricate changes in fine structure or cellular dynamics. Cryo-immobilize your aqueous samples under high pressure with a unique freezing principle and uncover secrets of the cellular process.

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