The Leica DM500 microscope with “plug and play” capability is the ideal tool to make teaching entry-level college and university Life Science courses easy and fun for the instructor and the student. The Leica DM750 is the ideal microscope for the versatile needs of advanced college and university life science courses and professional training in medical, veterinary and dental schools. EZStore™ design Auto Off (DM750) EZLite™ – provides over 20 years of bright, LED illumination which saves time and the cost of replacement bulbs. AgTreat™ – all touchpoints treated to prevent bacteria spreading from student to student. For: Brightfield (BF), Phase Contrast (PH), Darkfield (DF), Fluo (FL), Basic POL Plan-Acrhomatics objectives

The Leica DM1000 LED features long-life LED illumination that provides near daylight, bright illumination with constant colour temperature and emits less heat. The LED also eliminates the need for lamp changes, which saves time and money. Because of its low power consumption, the system is energy efficient. Users of the Leica DM1000 LED benefit from the system’s ability to uniquely adapt to every user. It is ideal for all clinical laboratory applications, especially for cytology, haematology, and pathology . For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) like in-vitro-fertilization (IVF). For: Brightfield (BF), Phase Contrast (PH), Darkfield (DF), Fluo (FL), Basic POL Objectives HiPlan / NPlan / PL Fluotar Nosepiece 5-fold Koehler Illumination Koehler Illumination Wide range of accessories

With their sophisticated modular design and high-performance fluorescence , the Leica DM2000 microscopes are ideal for complex tasks in pathology, cytology , and many other applications. For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) like in-vitro-fertilization (IVF). The Leica DM2000 microscopes can be configured with a variety of optics and contrast techniques to meet the specific requirements of demanding applications. Leica DM2000 is available in two versions, with bright halogen illumination, or with long-life LED. For: Brightfield (BF), Phase Contrast (PH), Darkfield (DF), Fluo (FL), POL Objectives Hi Plan / NPlan / PL Fluotar /PL APO Nosepiece 5 or 6 fold Koehler Illumination Height-adjustable focus knobs Wide range of accessories Integrated Adjustable Controls

Leica DM2500 & DM2500 LED optical microscopes are tools for demanding tasks in life science routine and research applications. With their transmitted light illumination, optical performance, and state-of-the-art accessories, they are especially well-suited for challenging life science research tasks that require differential interference contrast or high-performance fluorescence. The difference between the two optical microscopes is their illumination: DM2500 LED is equipped with LED illumination for transmitted light, DM2500 works with halogen. Both types of illumination render a realistic impression of the colours of the sample, so that users in clinical applications, such as the frequently used HE specimen staining, are able to assess the colours of their samples accurately. Designed with application-oriented modularity, the DM2500 & DM2500 LED can be configured to fit a wide variety of applications and accommodate the diverse physical requirements of individual users. For: Brightfield (BF), Phase Contrast (PH), Darkfield (DF), Fluo (FL), Advance POL, DIC Large selection of high class objectives Nosepiece 6 or 7 fold Koehler Illumination Height-adjustable focus knobs Wide range of accessories Integrated Adjustable Controls

The Leica DM3000 microscopes for pathology, cytology, haematology and many other applications feature a motorized nosepiece, condenser head, automated light intensity adjustment, and optional foot pedal . These intuitive microscopes improve workflows significantly. For special diagnostics requirements, the microscope is certified for in-vitro-diagnostics (IVD) like in-vitro-fertilization (IVF). The motorized condenser head knows the correct position for each magnification. The Leica DM3000 automatically adjusts the light intensity to each objective’s requirements, stores previously used light values for each magnification, and boosts efficiency when changing between two magnifications thanks to its unique toggle mode. For: Brightfield (BF), Phase Contrast (PH), Darkfield (DF), Fluo (FL), POL Large selection of high class objectives Motorized Nosepiece 6 Automated light adjustment Koehler Illumination Height-adjustable focus knobs Wide range of accessories Integrated Adjustable Controls Freely programmable control buttons

Increase your work efficiency with the Leica DM4 B or Leica DM6 B upright digital research microscopes! Both are ideally suited to making your work life easier in biomedical research and clinical labs alike. You can configure the microscope that fits your need and budget with the Leica DM4 B and Leica DM6 B. Optimize your system to your application with different contrast methods and automated functions. Simplify your workflow with automated functions and easy-to-use software. Easily capture publication-quality images by utilizing the 19-mm sCMOS camera imaging port Create fast overviews of your samples and identify the important details instantly with the LAS X Navigator Software Have great flexibility through the choice of accessories. Automated Upright Microscope System for Life Science and Clinical Applications Leica DM4 B Fully Automated Upright Microscope System for Life Science Research Leica DM6 B Transmitted Light Contrast Methods BF, PH, DF, POL, DIC Fluorescence Axis: Fully Automated Focus: Mechanical (DM4) / Mechanical or Motorized (DM6) LCD Display LAS X Navigator Software

Do you work in a field such as electrophysiology, evolutionary biology, or neuroscience where outstanding stability is required for successful experiments? The Leica DM6 FS fixed stage fluorescence microscope is a suitable instrument for your present and future challenges. Perform your experiment with a high degree of mechanical and electronic stability. Save time using the microscope’s full range of automated functions. Efficiently work with tools and accessories using special Leica optics that provide ample clearance around the specimen Add special techniques based on the Leica DM6 FS for Optogenetics and Cryo CLEM Vibration-free Operation

The Leica FS M manually-controlled forensic macroscope provides the flexibility, convenience, and comfort that make it the universal instrument of firearms and tool mark examiner. The versatile system is ideal for the simultaneous observation of evidence for training and consultation. The high-quality comparison bridge supports two precisely matched sets of apochromatically corrected objectives on quintuple ball-bearing nosepieces. Telecentric APO macro Telecentric APO macro objectives with built-in iris diaphragms further enhance contrast and increase the depth of field for the ultimate high contrast reproduction of evidence.

For industrial quality control and materials research, your goal is to deliver accurate and reliable results. You need software that enables you to work with speed, efficiency, and precision and facilitates your daily tasks. The Leica Application Suite X (LAS X) software allows you to do straightforward imaging and documentation for industrial applications. Observe your sample over the full screen. Configure the microscope system with individual user profiles. Make streamlined and flexible measurements when doing analysis. Enhance your imaging with stitching in X, Y, and Z Acquire and recall reliable and reproducible results. Customize report templates for your needs.

The Leica LAS EZ software, compatible with the Leica EZ4 W/E stereomicroscope, as well as the Leica EC4, Leica ICC50 W/E and Leica IC90 E digital cameras, provides an ideal common, easy-to-use, consistent platform for basic education, industry and life science applications. The Leica LAS EZ guides the user through the camera settings and shading corrections for high-quality imaging and allows the user to easily make annotations and basic measurements. Free hand annotation on the live and captured images.

The Aperio GT 450 enables histotechnicians to complete scanning tasks quickly and with confidence leveraging a 32-second scan speed*. Output 81 slides/hr at 40x* delivering high quality images with Leica optics and with an IT architecture that is secure and scalable. From the pathology lab to the IT room, the Aperio GT 450 is designed to scale up digital pathology operations. Improve case turnaround with no touch during scanning and continous loading of the racks directly from the HistoCore Workstation (Stainer & Coverslipper) Help increase IT security and control with a dedicated SAM (Scanner Admin Manager) server and software that allows you to set up and monitor multiple Aperio GT 450s at a time. No more single workstations for each scanner Ensure excellent image quality with Leica optics No touch continuous loading during scanning Automated IQ checks during each scan to ensure quality Assign priority cases Every slide is calibrated with each scan 450 slide capacity packed into a small size fits on the lab bench 99.5% accurate tissue finder that allows you to adjust if needed* 100% first-time barcode scan success rate*

ntroducing the Aperio AT2 DX System, a 400 slide scanner with Aperio ImageScope DX clinical viewing software, and a high-performance viewing workstation including color-calibrated medical grade monitors. The system can be used standalone, or in conjunction with Aperio Path DX case management software, for a streamlined, clinical workflow. Developed with proven technology from Leica Biosystems, the Aperio AT2 DX System enables high volume clinical labs to produce consistent, diagnostic quality images, enabling pathologists to diagnose with confidence. TAKE CONTROL OF YOUR TIME IN THE LAB 198% first time scan success Automated tissue finder 20x, 40x scanning options Z-stacking & manual adjustment for difficult samples Eliminate glass slide shipping & carrying DELIVER A CONFIDENT DIAGNOSIS Proven diagnostic quality Medical grade monitors with custom ICC color calibration Barcode linked for case assignment Seamless integration to case workflow

The Leica IC90 E CMOS microscope camera for stereo microscopes was developed for the Leica M series stereo microscopes. It provides pin-sharp images with spot-on color reproduction for professional visualization and documentation of industrial applications. Reveal more details with the 10megapixel resolution Directly connect to your microscope, no documentation tube needed. Connectivity made easy: Ethetnet, USB, HDMI The Leica IC90 E is designed to directly interface with your microscope. It is mounted between the tube and the optics carrier, so you don’t need a documentation tube nor a c-mount to operate the camera.

The Leica DFC3000 G is a grayscale USB 3.0 microscope camera for routine fluorescence applications. You will receive crisp images due to its unique passive cooling architecture and its highly sensitive CCD sensor. Correlated pixel double sampling together with a reduction of the ambient temperature of the sensor offers an exceptionally clear and noise -free signal. Its CCD sensor is particularly suitable for low light situations such as fluorescence and will capture even smallest amounts of light. Contrast Method: Fluorescence Passive cooling system with pixel double sampling and enhanced temperature convection Adaptable digitalization with 8, 12, and 16 bit Professional fluorescence documentation provided by a high-sensitivity 1.3megapixel CCD monochrome sensor from Sony® with micro lenses.

The K5 (grayscale) is ideal for routine fluorescence imaging applications such as immunostaining assays and 3D Cell Culture imaging. Image a wide variety of sample types with the flexibility and power of high 4.2megapixel resolution and fast 40 fps imaging brought to you by the K5. Contrast Method: Fluorescence Cooling method Passive cooling. Bring the flexibility and power of sCMOS technology into your lab and image the details of your experiment. Efficiently segment crucial real time events Improve signal-to-background of your THUNDER Imager. Reduce exposure times and phototoxic effects with high 80% quantum efficiency .

The DMC5400 color CMOS camera offers high frame rate & high-resolution color images even at low magnification. It is optimized to produce fast, high quality images for documentation, evaluation and analysis, for a wide variety of samples and applications in manufacturing and life science research. Contrast Method: BF →PH, DF, DIC, POL, IMC. Capture high-resolution images with 20 Megapixel sensor. Collect high-speed live images at up to 40 frames per second. See natural colors with unsurpassed accuracy. Easily connect with notebooks and PCs via USB 3.0 interface.

Leica DMC4500 color camera. It has been designed as a versatile, uncomplicated tool that simplifies the imaging process from capture through to processing. It is ideally suited to life science applications such as documenting slides and organisms, pathology or pharmaceutical testing and industrial applications such as quality control and failure analysis. Contrast Method: BF → PH, DF, DIC, POL, IMC USB 3.0 interface 5 megapixel CCD sensor Live image speed of up to 18 frames per second SXGA resolution of 1280 x 960 pixels

Microscopy – DMI Medical USA

Q: Laser Microdissection Microscopes Leica LMD6 & LMD7

Laser Microdissection (LMD, also known as Laser Capture Microdissection or LCM) enables users to isolate specific single cells or entire areas of tissue. Powered by a unique laser design and dynamic software, Leica LMD systems allow users to easily isolate Regions of Interest (ROI) from entire areas of tissue down to single cells or even subcellular structures such as chromosomes. LMD is typically used in genomics (DNA), transcriptomics (mRNA, miRNA), proteomics, metabolomics, and even next-generation sequencing (NGS). Researchers in neurology, cancer research, plant analysis, forensics or climate research rely on this method. Furthermore, LMD is a perfect tool for live-cell culture (LCC), for cloning and re-cultivation, manipulation or downstream analysis. We move the laser, not the sample. And we use gravity for collection. That is why our LMD systems provide you with perfectly cut, contamination-free, analysis-ready dissertates.

Q: THUNDER Imager Tissue

The THUNDER Imager Tissue allows real-time fluorescence imaging of 3D tissue sections typically used in neuroscience and histology research. Acquire rich, detailed images of thick tissues free of haze from out-of-focus blur. Even fine structures deep in tissues can be resolved thanks to Computational Clearing, an innovative Leica technology. Image detailed morphological structures like axons and dendrites of neurons in a brain slice. The high image quality, even with thick tissue sections, is combined with the well-known speed, fluorescence efficiency, and ease of use of widefield microscopes. Gain these advantages using a THUNDER Imager Tissue for your research: Rapidly acquire blur-free images showing the finest details of the morphology, even deep within thick sections Get fast overviews of whole tissue sections Image and analyze challenging tissue sections with an easy workflow Two Options for THUNDER Imager Tissue Choose the configuration which best meets your requirements: THUNDER Imager 3D Tissue is a fully automated tissue imaging system for recording multi-color 3D images. Capture multiple images in the z-direction and visualize them in the 3D viewer. Achieve excellent z-stack imaging due to a precise motorized focus drive. Decode 3D structures in real time. For brilliant imaging of single planes and fast overviews of your tissue the THUNDER Imager Tissue is also available in a cost-effective configuration without a motorized focus drive.

Q: Leica DM 1000 | Fluo-axis for 3 excitation cubes

Fluorescence is one of the most commonly used physical phenomena in biological and analytical microscopy, mainly because of its high sensitivity and high specificity. Fluorescence is a form of luminescence. Fluorescence microscopy even allows users to determine the distribution of a single molecule species, its amount and its localization inside a cell. Colocalization and interaction studies can be performed, and ion concentrations, as well as intra- and intercellular processes like endocytosis and exocytosis, can be observed. With the help of super-resolution fluorescence microscopy, it is even possible to image sub-resolution structures.